How do you make strychnine?
To prepare from this a D1 potency solution, 100 mL (= 1/10) of basic tincture is diluted with water to a volume of one liter. This corresponds to a dilution of 1:10 (where “D” = deca). This liter at D1 potency would still contain 0.36·1022 molecules of strychnine.
What is strychnine soluble in?
Solubility in water. 0.02% (20°C) Acidity (pKa) 8.25. Hazards.
What is the chemical formula of strychnine?
C21H22N2O2Strychnine / Formula
Is strychnine an antagonist?
Strychnine: a potent competitive antagonist of alpha-bungarotoxin-sensitive nicotinic acetylcholine receptors in rat hippocampal neurons.
What happens in strychnine poisoning?
Ten to twenty minutes after exposure, the body’s muscles begin to spasm, starting with the head and neck in the form of trismus and risus sardonicus. The spasms then spread to every muscle in the body, with nearly continuous convulsions, and get worse at the slightest stimulus.
Who invented strychnine?
strychnine, a poisonous alkaloid that is obtained from seeds of the nux vomica tree (S. nux-vomica) and related plants of the genus Strychnos. It was discovered by the French chemists Joseph-Bienaimé Caventou and Pierre-Joseph Pelletier in 1818 in Saint-Ignatius’-beans (S. ignatii), a woody vine of the Philippines.
Why was strychnine used in medicine?
Strychnine has been used for years as a medicinal remedy for a broad range of complaints. Strychnine is responsible for inhibiting postsynaptic glycine receptors, mostly in the spinal cord, causing painful, involuntary skeletal muscle spasms.
Can you survive strychnine?
If the person survives the toxic effects of strychnine poisoning, long-term health effects are unlikely. However, long-term effects may result from damage caused by the poisoning (for example, brain damage from low oxygen, kidney failure). People severely affected by strychnine poisoning are not likely to survive.