How does collagenase clostridium histolyticum work?

Collagenase Clostridium histolyticum injection is in a class of medications called enzymes. In people with Dupuytren’s contracture, it works by helping to break down the cord of thickened tissue and allows the finger(s) to be straightened.

How is collagenase administered?

As part of the protocol, each treatment cycle included two injections of CCH (0.58 mg) or placebo, directly injected into the primary plaque at the point of maximal penile curvature with an interval of approximately 24–72 hours between each injection.

What is collagenase ointment used for?

This product is used to help the healing of burns and skin ulcers. Collagenase is an enzyme. It works by helping to break up and remove dead skin and tissue.

What happens after xiaflex injection for Peyronie’s?

Receiving an injection of XIAFLEX® may cause damage to the tubes in your penis called the corpora. After treatment with XIAFLEX®, one of these tubes may break during an erection. This is called a corporal rupture or penile fracture. This could require surgery to fix the damaged area.

What are the side effects of xiaflex?

Common Xiaflex side effects may include:

  • swelling, bruising, bleeding, pain, or tenderness where the medicine was injected;
  • swollen glands in your elbow or underarm;
  • itching, redness, or warmth of the skin;
  • cracked skin;
  • underarm pain;
  • mild pain or tenderness in your treated hand;

How long does xiaflex last?

Your doctor will check your hand, try to straighten the finger if needed, and apply a splint. Wear the splint every night at bedtime as long as directed by your doctor (for up to 4 months).

What happens after XIAFLEX injection for Peyronie’s?

Does XIAFLEX work for Peyronie’s?

XIAFLEX ® (collagenase clostridium histolyticum) is the only nonsurgical treatment option for appropriate adult men with Peyronie’s disease approved by the Food and Drug Administration (FDA). Treatment involves a series of injections given by trained urologists in their office.