What are PAMAM dendrimers?

PAMAM dendrimers are a family of highly branched and mono-disperse synthetic macromolecules with well-defined structures and compositions. Synthesis of these nanocarriers can be carried out through the divergent route.

What are dendrimers made of?

Dendrimers are nearly monodisperse macromolecules that contain symmetric branching units built around a small molecule or a linear polymer core [5-7]. ‘Dendrimer’ is only an architectural motif and not a compound.

What is polyaminoamide?

Polyamidoamine-epichlorohydrin (PAE), a polyelectrolyte typically used as wet-strength agent, is commonly used in filter papers and paper towels, which are often used as substrate in bioactive paper. However, the effect of cellulose or polymeric additives on antibody bioactivity is unknown.

Why are dendrimers used in drug delivery?

Due to their unique characteristics, dendrimers have attracted a great deal of attention over the past few years. The reason why they are of eminent interest in drug-delivery applications is that they have uniform size, water solubility, modifiable surface functionality and available internal cavities.

What is the meaning of Pamam?

Poly(amidoamine), or PAMAM, is a class of dendrimer which is made of repetitively branched subunits of amide and amine functionality.

How are dendrimers formed?

Dendrimers are constructed by the successive addition of layers to the branching groups. The synthesis of dendrimers involves a core molecule with branching groups to which other branching molecules are added (see figure below) in layers. Each new layer is called a generation.

What are dendrimers in nanotechnology?

Dendrimers represent a class of novel polymers having unique molecular architectures characterized by their well-defined structure, with a high degree of molecular uniformity, low polydispersity and properties that make them attractive materials for the development of nanomedicines.

What does Pamam stand for?

How can dendrimers aid in therapeutic delivery?

The dendrimer architecture has three main sites for drug entrapment by using various mechanisms: (i) void spaces (by molecular entrapment); (ii) branching points (by hydrogen bonding); and (iii) outside surface groups by (charge–charge interactions) (Figure 1).

What are some desirable features of dendrimers for drug delivery?

[23] Unlike traditional polymers, dendrimers have received considerable attention in biological applications due to their high water solubility,[24] biocompatibility,[25] polyvalency[12] and precise molecular weight. [26] These features make them an ideal carrier for drug delivery and targeting applications.

Are dendrimers nanoparticles?

Among all the type of nanoparticles, dendrimers display several advantages, which make them ideal candidates for improved and targeted drug delivery in cancer research. Dendrimers can transport large amounts of drug into specific areas.