What are PNNs?

Perineuronal nets (PNNs) are specialized extracellular matrix structures responsible for synaptic stabilization in the adult brain. PNNs are found around certain neuron cell bodies and proximal neurites in the central nervous system.

What are PNNs made of?

PNNs are composed of CSPGs versican, brevican, neurocan, cat- 301 antigen (aggrecan), phosphacan (DSD-1-PG), HA, tenascin-C, tenascin-R (TN-R), and link proteins (4 –9).

What are the dietary guidelines for France?

These messages are as follows: “For your health, practice a physical activity regularly”; “For your health, eat at least five fruit and vegetables per day”; “For your health, avoid eating too much fat, sugar, salt”; “For your health, avoid snacking between meals”.

What are the top diet related diseases in France?

Poor nutritional status is one of the greatest risk factors in several chronic diseases, including cardiovascular disease (CVD),7 cer- tain cancers, obesity, diabetes, and osteoporosis (1–3).

Is chondroitin sulfate a proteoglycan?

Chondroitin sulfate proteoglycans (CSPGs) are proteoglycans consisting of a protein core and a chondroitin sulfate side chain. They are known to be structural components of a variety of human tissues, including cartilage, and also play key roles in neural development and glial scar formation.

What does WFA stain for?

It is generally accepted that WFA stains a majority of PNs, but not all types. Ajmo et al. (2008) found that staining with WFA and an antibody to the CSPG brevican identified some PNs that were brevican-reactive, some PNs that were WFA-reactive, and some PNs that were reactive for both markers.

Is aggrecan a gag?

Almost 90% of aggrecan mass is comprised of substituted GAG chains which are mostly chondroitin sulfate chains, but also include keratan sulfate chains with N- and O-linked oligosaccharides.

What is the French food pyramid?

This is a french food guide pyramid. It recommends you have 100-150g of meat or fish, a dairy product at each meal,five portions of 80-100g of fruit and vegetables, grain products at each meal and of course plenty of water.

Does France have a food pyramid?

After sweets, fatty meat delicacies such as foie gras and paté follow in the pyramid. These can be eaten on a weekly basis. On a day-to-day basis a protein such as your basic meat/poultry/fish/eggs should be eaten 1-2 times a day. Dairy products and grains are eaten in moderation at nearly every meal.

What’s the leading cause of death in France?

Cancer is the leading cause of death in France, accounting for 28.5% of all deaths in 2014, followed by cardiovascular diseases, which accounted for 25%. However, there are gender differences (Figure 2): 33% of all deaths among men were related to cancer, while this proportion was lower among women (24%).

What are the 5 leading causes of death in France?


Cause Of Death Rnk Deaths
Coronary Heart Disease 1 74,286
Alzheimers & Dementia 2 59,513
Lung Cancers 3 40,850

Is hyaluronic acid a proteoglycan?

Biology of the Extracellular Matrix The most prominent and ubiquitousprotein-free GAG is hyaluronic acid, a giant polysaccharide composed of thousands of N-acetylglucosamine/glucuronic acid disaccharides. However, other GAGs bind to proteins via a serine hydroxyl group, forming a proteoglycan (Fig. 95.8)15.