What does ethinyl estradiol bind to?
Enthinylestradiol is 98.3-98.5% bound to albumin in serum 8 but also exhibits binding to sex hormone binding globulin. Ethinylestradiol can be glucuronidated by UGT1A1, UGT1A3, UGT1A4, UGT1A9, and UGT2B7. Ethinylestradiol is also sulfated by SULT1A1, SULT1A3, and SULT1E1.
Is ethinyl estradiol orally active?
Orally, EE is on the order of 100 times as potent by weight as natural estrogens like micronized estradiol and conjugated estrogens, which is largely due to substantially greater resistance to first-pass metabolism.
What is the mechanism of action for estradiol?
Estradiol acts on the on the estrogen receptors to relieve vasomotor systems (such as hot flashes) and urogenital symptoms (such as vaginal dryness and dyspareunia). Estradiol has also been shown to exert favorable effects on bone density by inhibiting bone resorption.
What are estrogenic activities?
Chemicals that mimic or antagonize the in vitro and/or in vivo actions of naturally occurring estrogens such as 17β-estradiol (E2) are typically defined as having estrogenic activity (EA) or anti-estrogenic activity, and effects on estrogen signaling represent the most common and best studied endocrine disruptor …
What is the meaning of ethinyl estradiol?
Definition of ethinyl estradiol : a very potent synthetic estrogen C20H24O2 used especially as an oral contraceptive.
Does ethinyl estradiol increase breast size?
Starting to take the pill can stimulate the breasts to grow. However, any increase in size is typically slight. Within a few months of taking the pill, the breasts generally return to their regular size. This usually also happens if a person stops taking the pill.
Does Mylan prevent pregnancy?
Mylan is a pharmaceutical company that manufactures generic medications including certain kinds of birth control. Mylan birth control comes in a pill or patch form, and each type contains different hormones that prevent pregnancy.
What is the half life of estradiol?
Pharmacokinetics of estradiol
| Clinical data | |
|---|---|
| Elimination half-life | Oral: 13–20 hours Sublingual: 8–18 hours Transdermal (gel): 37 hours IM (as EV ): 4–5 days IM (as EC ): 8–10 days IV (as E2 ): 0.5–2 hours |
| Excretion | Urine: 54% Feces: 6% |
What provides the greatest estrogenic activity?
There are three major endogenous estrogens that have estrogenic hormonal activity: estrone (E1), estradiol (E2), and estriol (E3). Estradiol, an estrane, is the most potent and prevalent.