What does leukemia inhibitory factor do?

Leukemia inhibitory factor (LIF), a secreted cytokine, plays an important role in a wide array of biological processes including inducing differentiation of leukemia cell, inflammatory response, neuronal development, embryonic implantation, stem cell self-renewal and cancer progression, etc.

What is the LIF gene?

LIF (LIF Interleukin 6 Family Cytokine) is a Protein Coding gene. Diseases associated with LIF include Leukemia and Myeloid Leukemia. Among its related pathways are Cytokine Signaling in Immune system and PEDF Induced Signaling.

Is LIF a cytokine?

Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that affects cell growth by inhibiting differentiation. When LIF levels drop, the cells differentiate.

What is Lif stem cells?

Leukemia inhibitory factor (LIF) is a member of the interleukin-6 (IL-6) cytokine family. All members of this family activate signal transducer and activator of transcription 3 (STAT3), a transcription factor that influences stem and progenitor cell identity, proliferation and cytoprotection.

What is inhibitory factor?

A factor that inhibits the secretion of hormones, as opposed to a releasing Factor.

Is LIF a growth factor?

Leukemia inhibitory factor (LIF): a growth factor with pleiotropic effects on bone biology. Prog Growth Factor Res. 1992;4(4):337-53. doi: 10.1016/0955-2235(92)90015-a.

Is LiF ionic or molecular?

LiF is lithium fluoride. This is an example of a binary ionic compound, which consists of two elements, a cation and anion. Since lithium, the metal has a plus one charge, and fluoride, a nonmetal, has a negative charge, these two ions are held together through an ionic bond.

Why LIBR and LiI is covalent in nature?

Hint: The Lithium ion being small in size can easily distort the electron cloud of an anion thereby leading to the formation of a covalent bond. As the lithium is small in size, higher is the size of anion; higher will be the covalent character in bond.

Why LiI is covalent in nature?

Li+ ion is very small in size and has high tendency to distort electron cloud around the negative halide ion. Anion with large size can be easily distorted hence among halides, lithium iodide is the most covalent in nature.