What is BerEp4 positive?
BerEp4 has a high sensitivity and specificity in being positive only in BCC cells. BerEp4 is normally negative in squamous epithelium and mesothelium, but otherwise normally positive most epithelial cells of the body.
How do you differentiate between BCC and SCC?
BCCs are directly related to sun exposure and are usually easily treated. SCCs are related to smoking, too much alcohol, and a weak immune system (such as being on chemotherapy or other medicines that suppress the immune system). They are harder to treat than BCCs but can still usually be treated well.
What is Basaloid squamous cell carcinoma?
Basaloid squamous cell carcinoma (BSCC) is a rare and aggressive variant of oral squamous cell carcinoma with a predilection for the tongue and in other locations, such as floor of the mouth, palate, retromolar trigone, and gingival mucosa.
What does berep4 stand for?
Epithelial cell adhesion molecule/EPCAM (Ber-EP4) is expressed on most epithelial cells of the body, with the exception of squamous epithelium and mesothelium. It has been used to distinguish basal cell carcinoma from squamous cell carcinoma of the skin, and to distinguish pulmonary adenocarcinoma from mesothelioma.
What does TTF 1 positive mean?
TTF-1 plays a key role in morphogenesis of the lungs and is expressed in up to 90% of pulmonary small cell carcinoma. This explains why this marker is frequently used to search for the primary origin of metastatic neuroendocrine tumours.
Which is worse SCC or BCC?
Though not as common as basal cell (about one million new cases a year), squamous cell is more serious because it is likely to spread (metastasize).
What does SCC look like?
What does SCC look like? SCCs can appear as scaly red patches, open sores, rough, thickened or wart-like skin, or raised growths with a central depression. At times, SCCs may crust over, itch or bleed. The lesions most commonly arise in sun-exposed areas of the body.
What causes Basaloid squamous cell carcinoma?
In basaloid squamous cell carcinoma, the DNA that controls these cells is damaged, leading to an overgrowth of cells that forms a tumor. The exact cause of why this happens in some people and not others is unknown, but factors like smoking and drinking alcohol may be related to the cause of this cancer.
Is Basaloid squamous cell carcinoma treatable?
Here, we present a rare case of the successful treatment of basaloid squamous cell carcinoma in the rectosigmoid colon. The patient with this rare tumor has the longest survival, and thus, curative resection and chemotherapy may play important roles in improving survival.
Is CK7 positive good?
For CK7, staining in > 10% of tumor cells was considered a positive sample. For CK20, staining in > 25% of tumor cells was considered positive (Fig. 1). Concerning MMR status, tumors with any apparent nuclear staining with MSH2, MSH6, PMS2, and MLH1 were considered MMR-proficient.
What does CK7 stain for?
CK7 will variably stain the majority of cells in biliary and gastric tumors. 3. Carcinomas that are almost invariably negative but may occasionally show rare CK7-positive cells include hepatomas, duodenal ampulla carcinomas, colon carcinomas, and adrenal cortical tumors.