What is colistin used for?

Colistimethate is an antibiotic used to treat certain bacterial infections. It works by stopping the growth of bacteria.

What infections are treated with colistin?

Colistin is highly active against many strains of aerobic gram-negative bacteria, including Acinetobacter, Citrobacter, E. coli, Enterobacter, H. influenzae, Klebsiella, Morganella morganii, P. aeruginosa, Salmonella, Shigella, and variable numbers of Stenotrophomonas strains.

What kind of antibiotic is colistin?

Colistin is a polymyxin antibiotic used to treat bacterial infections caused by susceptible Gram negative bacteria.

What is the action of colistin?

Colistin binds to LPSs and phospholipids in the outer cell membrane of Gram-negative bacteria. It competitively displaces divalent cations (Ca2+ and Mg2+) from the phosphate groups of membrane lipids, which leads to disruption of the outer cell membrane, leakage of intracellular contents and bacterial death (Figure 3).

Is colistin safe for babies?

Conclusions: Colistimethate intravenous administration appears to be safe and efficacious for multidrug-resistant Gram-negative infections in neonates, including preterm and extremely low birth weight neonates.

Is colistin safe in pregnancy?

Colistimethate Pregnancy Warnings Colistimethate crosses the placenta and should only be given during pregnancy when benefit outweighs risk.

How is colistin given?

Colistimethate Sodium is administered intravenously as a slow infusion over 30 – 60 minutes.

Why is colistin banned in India?

Now, the Central Government in exercise of the powers conferred by section 26A2 of the Drugs and Cosmetics Act, 1940, and also agreeing with DTAB recommendation, has announced the immediate ban of Colistin for the use of promoting growth in livestock.

What are the side effects of colistin?

Common side effects of colistin include: Dizziness. Numbness, tingling, prickling, burning sensation especially of extremities and tongue….Other side effects of colistin include:

  • Slurred speech.
  • Spinning sensation (vertigo)
  • Seizures.
  • Severe allergic reaction (anaphylaxis)

Can colistin be given orally?

GENERIC NAME: COLISTIN SULFATE – ORAL SUSPENSION (ko-LIST-in SULL-fate) USES: This medication is used to treat certain stomach, bowel and digestive tract infections. HOW TO USE: Take this medication by mouth as directed. This may be taken with food if stomach upset occurs.

How do you dilute colistin?

Reconstitution and administration guideline Colymycine® (Colistin/CMS) contains 1 MU per vial. Each vial should be reconstituted with 5 ml of 0.9% sodium chloride. Further dilute to a final volume of 50 ml for maintenance dosages and 100 ml for the loading dosage.

How do you use colistin injection?

Quick tips

  1. Colistin Injection is an antibiotic that is usually only given in the hospital for serious infections.
  2. It is given by injection or drip (infusion) into a vein usually over 30-60 minutes.
  3. Finish the prescribed course, even if you start to feel better.
  4. Diarrhea may occur as a side effect.