What is Endophilic?

Adjective. endophilic (not comparable) Living inside an enclosed space such as a burrow, crack, cave or building as opposed to living outdoors (exophilic) quotations ▼

What is the Exoerythrocytic cycle?

In the exoerythrocytic stage, sporozoites from the mosquito’s saliva asexually multiply for about 7–28 days in liver cells before differentiating into invasive merozoites which enter the bloodstream to initiate the erythrocytic phase.

What is Sporogonic cycle?

The parasites’ multiplication in the mosquito is known as the sporogonic cycle . While in the mosquito’s stomach, the microgametes penetrate the macrogametes generating zygotes . The zygotes in turn become motile and elongated (ookinetes) which invade the midgut wall of the mosquito where they develop into oocysts .

Why is primaquine given with chloroquine?

vivax malaria are treated with chloroquine for three days to eliminate the parasites in the blood that cause the symptoms of malaria, followed by 15 mg/day of primaquine for 14 days to treat the liver stage of the infection to prevent the disease recurring.

What is the difference between Exoerythrocytic and Erythrocytic schizogony?

Two distinct types of merogony are observed. The first, called exoerythrocytic schizogony, occurs in the liver and is initiated by the sporozoite. The resulting merozoites then invade erythrocytes and undergo repeated rounds of merogony called erythrocytic schizogony.

What is malaria recrudescence?

“Recrudescence” is the term for recurrence of infection with all malaria species including P. falciparum, P. malariae and P. knowlesi, which lack hypnozoites. This occurs when the infection (unless a new infection) has persisted in the blood at undetectable levels and then becomes detectable again.

What is malaria hypnozoites?

Hypnozoites are dormant malaria parasites that can reactivate and cause relapses of malarial disease. They are an important factor in malaria biology and in the feasibility of malaria elimination programmes.

What is sporozoite and merozoite?

The key difference between merozoites and sporozoites is that merozoites are the form of malaria parasite that infects red blood cells, while sporozoites are the form of malaria parasite that infects liver cells. Plasmodium is a parasitic protozoan. It is the causative agent of malaria.

What is sporogony and Gametogony?

Gametogony begins within the erythrocytes of the vertebrate host and is completed within the mosquito where sporogony takes place. This life cycle exhibits the general features of other apicomplexan parasites characterized by asexual replication and the formation of invasive stages with typical apical organelles.

What is the difference between primaquine and chloroquine?

Chloroquine is a highly effective schizontocide, while primaquine has weaker asexual-stage activity (3) but is the only generally available drug with hypnozoitocidal properties, i.e., it kills dormant liver stage parasites and prevents relapse (radical cure) (1).