What is the Immunophenotype of mycosis fungoides?

Concept: mycosis fungoides It corresponds to the cutaneous lymphoma originated in the peripheral epidermotropic T-lymphocyte, which expresses the T-cell receptor (TCR) with αβ+subunits and CD4+ immunophenotype, known as memory T-lymphocyte (CD45RO+), and constitutes the skin immunosurveillance.

What is Sézary syndrome?

Sézary syndrome is an aggressive form of a type of blood cancer called cutaneous T-cell lymphoma. Cutaneous T-cell lymphomas occur when certain white blood cells, called T cells, become cancerous; these cancers characteristically affect the skin, causing different types of skin lesions.

Is Sézary syndrome hereditary?

In people affected by the condition, the cancerous T- cells (also called Sezary cells) usually have one or more chromosomal abnormalities . These genetic changes are considered “somatic” because they are acquired during a person’s lifetime, are not inherited and only affect the DNA of the cancerous cells.

What is Waldenstrom syndrome?

Waldenstrom macroglobulinemia (mak-roe-glob-u-lih-NEE-me-uh) is a rare type of cancer that begins in the white blood cells. If you have Waldenstrom macroglobulinemia, your bone marrow produces too many abnormal white blood cells that crowd out healthy blood cells.

How long can you live with Sézary syndrome?

Median survival for patients with Sezary syndrome has been reported to be 2 to 4 years after development of the condition, although survival has improved with newer treatments. The disease-specific 5-year survival rate has been reported to be 24%.

What is Sézary cells?

(sey-zah-REE sel) A cancerous T cell (a type of white blood cell) found in the blood, skin, and lymph nodes of patients who have a fast-growing type of skin lymphoma called Sézary syndrome. Under a microscope, Sézary cells have an abnormally shaped nucleus and look larger than normal T cells.