What is the normal role of ICAM-1?
Role in cell signaling ICAM-1 is an endothelial- and leukocyte-associated transmembrane protein long known for its importance in stabilizing cell-cell interactions and facilitating leukocyte endothelial transmigration. More recently, ICAM-1 has been characterized as a site for the cellular entry of human rhinovirus.
What is ICAM in immunology?
The intercellular adhesion molecule (ICAM) 1 is an Ig-like cell adhesion molecule expressed by several cell types, including leukocytes and endothelial cells.
What does ICAM 2 do?
ICAM2 may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance.
What is ICAM and VCAM?
Intercellular adhesion molecule 1 (ICAM-1) and vascular cell adhesion molecule 1 (VCAM-1) are endothelial CAMs of the immunoglobulin (Ig) superfamily with a critical role in mediating the firm adhesion of leukocytes to endothelial cells in various acute and chronic inflammatory diseases.
Where are Icams found?
The membrane-bound form of ICAM-1 serves as a counter receptor for the β2-integrins, CD11a/CD18 (LFA-1) and CD11b/CD18 (Mac-1), found on leukocytes. Interactions with membrane-bound ICAM-1 facilitate leukocyte transmigration across the endothelium of many cell types.
Where is ICAM expressed?
Although ICAM-1 is expressed constitutively at low levels on endothelial cells and on some lymphocytes and monocytes, its expression can be significantly increased in the presence of cytokines (TNFalpha, IL-1, IFNgamma) and reactive oxygen species.
Is VCAM an integrin?
VCAM-1 is a ligand for the α4β1 integrin (VLA-4) and binds weakly to α4β7 (102,205–207). A single VCAM-1 gene gives rise through alternative splicing to distinct isoforms (204, 208–211). The major form of VCAM-1 in humans contains seven Ig domains of which domains 1–3 are homologous to domains 4–6 (204).
What does ICAM stand for biology?
In molecular biology, intercellular adhesion molecules (ICAMs) and vascular cell adhesion molecule-1 (VCAM-1) are part of the immunoglobulin superfamily. They are important in inflammation, immune responses and in intracellular signalling events.
Do integrins bind to Icams?
The ICAM family consists of five members, designated ICAM-1 to ICAM-5. They are known to bind to leucocyte integrins CD11/CD18 such as LFA-1 and Macrophage-1 antigen, during inflammation and in immune responses.
What does VCAM stand for?
|Vascular Cell Adhesion Molecule
|Virtual Communications Access Method
|Versatile Channel Assignment Mode
What is the role of adhesion?
Adhesion molecules are known to -be important components of an active T-cell mediated immune response. Signals generated at a site of inflammation cause circulating T cells to respond by rolling, arrest and then transmigration through the endothelium, all of which are mediated by adhesion molecules.