What happens when you metabolize fructose in excess?

While every cell in the body can use glucose, the liver is the only organ that can metabolize fructose in significant amounts. When people eat a diet that is high in calories and high in fructose, the liver gets overloaded and starts turning the fructose into fat.

What diet does Dr Lustig recommend?

In an ideal world, says Lustig, we’d just switch to a whole food diet packed with fruits, veggies, whole grains, unprocessed meat, fish and so on, but in reality, the packaged food industry is going to try and find ways to give us the processed foods we are accustomed to (ketchup, soda, cookies) where sucrose is …

How does the body metabolize fructose?

Fructose is metabolized, primarily in the liver, by phosphorylation on the 1-position, a process that bypasses the rate-limiting phosphofructokinase step (4).

How long does it take to metabolize fructose?

The mean oxidation rate of dietary fructose was 45.0% ± 10.7 (mean ± SD) in non-exercising subjects within 3–6 hours and 45.8% ± 7.3 in exercising subjects within 2–3 hours.

What diseases does Lustig attribute to sugar?

It’s omnipresent in our food supply (77% of the foods in the America food supply include added sugar), and plays a huge role in metabolic syndrome, which leads to diseases like diabetes: Lustig cited a study that showed while eating an extra 150 calories per day did not increase diabetes prevalence worldwide, if those …

What does Dr Lustig claim sugar is the proximate cause of?

Lustig argues that sugar creates an appetite for itself by a determinable hormonal mechanism – a cycle, he says, that you could no more break with willpower than you could stop feeling thirsty through sheer strength of character. He argues that the hormone related to stress, cortisol, is partly to blame.

Which enzyme breaks down fructose?

Fructose metabolism in the liver involves phosphorylation by the enzyme fructokinase followed by a split in the resulting product, fructose-1-phosphate, into glyceraldehyde and dihydroxyacetone phosphate by the enzyme aldolase B.

How is mannose metabolized?

Human plasma contains ~50μM mannose which is primarily derived from N-glycan processing [19]. Mannose is absorbed through the intestine and metabolized. A bolus of <0.2g/Kg body weight increases mannose concentration by 3-fold with a clearance T1/2 of ~ 4hr, without affecting glucose concentration.

What helps break down fructose?

There is no known cure, but an appropriate diet and the enzyme xylose isomerase can help. The ingestion of glucose simultaneously with fructose improves fructose absorption and may prevent the development of symptoms.