What does secondary progressive MS mean?

Secondary progressive MS (SPMS) is a stage of MS which comes after relapsing remitting MS for many people. With this type of MS your disability gets steadily worse. You’re no longer likely to have relapses, when your symptoms get worse but then get better.

Is Tysabri for SPMS?

Tysabri is approved by the U.S. Food and Drug Administration (FDA) as a monotherapy (not to be used in combination with other disease-modifying therapies) for the treatment of relapsing forms of multiple sclerosis, which include clinically isolated syndrome, relapsing-remitting disease (RRMS) and active secondary …

Is natalizumab a biologic?

Tysabri contains the active drug natalizumab. This is a type of biologic drug (made from parts of living organisms) called an integrin receptor antagonist.

Is secondary progressive MS fatal?

Though the disease will progress, it’s important to treat SPMS as early as possible. There’s no cure, but MS isn’t fatal, and medical treatments can significantly improve quality of life. If you have RRMS and are noticing worsening symptoms, it’s time to talk to your doctor.

How quickly does secondary progressive MS progress?

When does the transition occur? Prior to the availability of the approved disease-modifying therapies, studies indicated that 50 percent of those diagnosed with relapsing-remitting MS (RRMS) would transition to secondary-progressive MS (SPMS) within 10 years, and 90 percent would transition within 25 years.

Is PML the same as MS?

Progressive multifocal leukoencephalopathy (PML) is a serious infective disease of the central nervous system that may occur in case of severe immunosuppression or after some treatment for multiple sclerosis (MS) with natalizumab, dimethyl fumarate, and fingolimod.

What is the best drug for secondary progressive MS?

Immune suppressive drugs in secondary progressive multiple sclerosis. Mitoxantrone is the only approved drug by the US Food and Drug Administration (FDA) for SPMS, PRMS, and worsening RRMS.

What is the life expectancy of a person with secondary progressive MS?

Currently available data indicate that the average life expectancy for MS patients is five to 10 years shorter than people without MS. For reference, in the U.S., the average life expectancy is 81 years for women and 76 years for men.